Black-footed ferrets are susceptible to a number of infectious diseases including influenza, numerous intestinal parasites and tularemia. The two diseases of greatest concern to the captive and reintroduced populations are sylvatic plague and canine distemper. These diseases have been attributed to the decline and extinction of wild ferret populations.

  • Black-tailed prairie dog dead from plague. Credit: T. Livieri/ Prairie Wildlife Research

Sylvatic Plague

Sylvatic plague is a form of bubonic plague, which is known as the “Black Death” and is responsible for 25 million human deaths in the 1300s. It is caused by the bacteria Yersinia pestis. Rats are the primary host and fleas transmit the disease to other animals and people. Due to increased hygiene and the advent of antibiotics, the threat of plague to humans is minimal.

Plague is a non-native disease to the Americas. It was introduced to San Francisco in the early 1900s from rats on Asian trading ships. It has since been moving eastward. Prairie dogs and black-footed ferrets are both highly susceptible to the disease. The bacteria spread rapidly through prairie dog colonies via infected fleas, and cause close to 100% mortality of prairie dogs. Plague is 100% fatal in black-footed ferrets. They become infected by fleas, or by eating prairie dogs that are infected or have died from plague. The spread of sylvatic plague across the grasslands further fragments prairie dog colonies, making large areas of habitat unsuitable for black-footed ferrets.

However, a vaccine developed by the US Army and the US Geological Survey has proven to be effective at preventing the disease in black-footed ferrets. This vaccine is an injection followed by a booster about 3 weeks later, and appears to provide life-long immunity to plague. All captive ferrets receive this vaccine prior to being released into the wild. Efforts are ongoing to capture and vaccinate wild-born black-footed ferrets. While vaccination of captive ferrets is fairly easy, vaccination of wild-born ferrets is time consuming and labor intensive.

Dusting prairie dog burrows with a pesticide aids in preventing outbreaks of plague by decreasing the number of fleas. This is a strategy conducted at many of the black-footed ferret reintroduction sites. This is also very labor intensive, time consuming, and costly.

While vaccination of ferrets and dusting prairie dog burrows are excellent tools in the fight against plague, they are not long-term solutions. Currently, efforts are underway to develop an oral plague vaccine for prairie dogs. The hope is that if the prairie dogs are immune to plague, it will not spread through the colony and ferrets will not contract the disease (called “herd immunity”).

Canine Distemper

Canine distemper is caused by a virus called a paramyxovirus. It is commonly associated with domestic dogs and domestic ferrets, but is also found in wild canids, mustelids and other animals. It can cause respiratory illness, gastrointestinal illness, neurological problems, and eventually death. It is spread by contact with infected respiratory droplets, feces, urine and bodily fluids.

The mortality rate in black-footed ferrets approaches 100%. Distemper is not as common or devastating as plague, but can still pose a threat to isolated ferret populations. Prairie dogs are not susceptible to the disease.

There is now a safe and effective vaccine against canine distemper for black-footed ferrets. It is a recombinant canarypox vectored vaccine. This vaccine requires an initial dose, then a booster 3-4 weeks later. It is administered to all captive ferrets prior to release and any wild ferrets that are captured during routine surveys.

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